When Does Mlb Season Start 2025. 2025 championship season to open with the tokyo series presented by guggenheim between the los angeles dodgers and the chicago cubs; The 2025 mlb season actually begins between the los angeles dodgers and chicago cubs in japan on march 18.

On that day, as part of interleague matchups, the yankees will face off the brewers and the mets will. Teams begin their spring training games in late february or early march and the actual 2025 mlb season is set to being on thursday march 27th, with all teams playing that day.